miRNA function in neuronal homeostasis

In this project, we want to understand how miRNA-dependent regulation of neuronal targets contributes to homeostatic forms of synaptic plasticity. We have identified specific microRNAs that are required for homeostatic synaptic depression, a form of plasticity that is engaged during extended periods of high neuronal activity, i.e. those encountered during epileptic seizure activity. We are interested in the relevance of this regulation for brain development and pathology, in particular epilepsy.